What are the eligibility criteria for use of alteplase in thrombolytic therapy for acute ischemic stroke (AIS)?

Updated: Aug 04, 2021
  • Author: Wanda L Rivera-Bou, MD, FAAEM, FACEP; Chief Editor: Erik D Schraga, MD  more...
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The eligibility criteria in the extended time period of 3 to 4.5 hours are similar to those for patients treated at earlier time periods. In addition, the following exclusion criteria must be considered: patients older than 80 years, those taking oral anticoagulants regardless of their INR, those with an NIH Stroke Scale score higher than 25, and those with both a history of stroke and diabetes.

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