What are thrombolytic regimens for urokinase for treatment of central venous catheter occlusion?

Updated: Aug 04, 2021
  • Author: Wanda L Rivera-Bou, MD, FAAEM, FACEP; Chief Editor: Erik D Schraga, MD  more...
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The urokinase dose for catheter clearance is 5000 U in each lumen over 1-2 minutes; this is left in the lumen for 1-4 hours and then aspirated. If 5000 U fails to clear the catheter, the process may be repeated with 10,000 U in each lumen. The volume to be instilled into the catheter is equal to the volume of the catheter. For patients undergoing dialysis, instill 5000 U into each lumen over 1-2 minutes, leave the agent in the lumen for 1-2 days, and then aspirate.

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