What is the role of unfractionated heparin (UFH) in thrombolytic therapy for pulmonary embolism (PE)?

Updated: Aug 04, 2021
  • Author: Wanda L Rivera-Bou, MD, FAAEM, FACEP; Chief Editor: Erik D Schraga, MD  more...
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Unfractionated heparin (UFH) should not be given concomitantly with fibrinolytic therapy in acute massive PE. After fibrinolytic therapy, anticoagulation treatment is recommended to prevent recurrent thrombosis. Do not begin heparin until the activated partial thromboplastin time (aPTT) has decreased to less than twice the normal control value.

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