What are the thrombolytic therapy regimens for alteplase in patients with acute myocardial infarction (AMI)?

Updated: Aug 04, 2021
  • Author: Wanda L Rivera-Bou, MD, FAAEM, FACEP; Chief Editor: Erik D Schraga, MD  more...
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Alteplase can be administered in an accelerated infusion (1.5 hr) using 50-mg and 100-mg vials reconstituted with sterile water to 1 mg/mL. Accelerated infusion of alteplase for AMI consists of a 15-mg IV bolus followed by 0.75 mg/kg (up to 50 mg) IV over 30 minutes and then 0.5 mg/kg (up to 35 mg) IV over 60 minutes. The maximum total dose is 100 mg for patients weighing more than 67 kg. This is the most common alteplase infusion parameter used for AMI.

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