What are the principal clinical syndromes that may require thrombolytic therapy?

Updated: Aug 04, 2021
  • Author: Wanda L Rivera-Bou, MD, FAAEM, FACEP; Chief Editor: Erik D Schraga, MD  more...
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Under pathologic conditions, a thrombus can propagate into otherwise normal vessels. A thrombus that has propagated where it is not needed can obstruct flow in critical vessels; it can also obliterate valves and other structures that are essential to normal hemodynamic function. The principal clinical syndromes that result are as follows:

  • Acute myocardial infarction (AMI)
  • Deep vein thrombosis (DVT)
  • Pulmonary embolism (PE)
  • Acute ischemic stroke (AIS)
  • Acute peripheral arterial occlusion
  • Occlusion of indwelling catheters

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