What is the role of meperidine in emergency department (ED) sedation?

Updated: Nov 06, 2018
  • Author: Arul M Lingappan, MD; Chief Editor: Erik D Schraga, MD  more...
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Meperidine's duration of action (2-3 h) is intermediate when compared with fentanyl and morphine. Intravenous dosing is 0.5-1 mg/kg initially (35-100 mg for adults). It has an active metabolite, normeperidine, that can lower the seizure threshold, and it becomes problematic in renal failure. It offers no advantage over fentanyl or morphine. It is rarely used in procedural sedation.

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