What is the role of thiopental in pediatric sedation?

Updated: May 08, 2018
  • Author: Wan-Tsu Wendy Chang, MD; Chief Editor: Ted Rosenkrantz, MD  more...
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Thiopental can be used as an induction agent for endotracheal intubation. It decreases ICP. Its onset of action occurs within 30-40 seconds, and its half-life is 3-8 hours (though it may be prolonged with repeat doses because of accumulation in fatty tissues).

Induction dosing is 2-5 mg/kg/dose IV; no specific initial dose is recommended, because of the great variability of patient response. Age, sex, and body weight all affect dosing. Pediatric patients often need doses that are larger (on a milligram-per-kilogram basis) than those used for adults or elderly persons.

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