What is the role of morphine in pediatric sedation?

Updated: May 08, 2018
  • Author: Wan-Tsu Wendy Chang, MD; Chief Editor: Ted Rosenkrantz, MD  more...
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Morphine sulfate

Morphine sulfate is indicated for analgesia because of its reliable and predictable effects, good safety profile, and ease of reversibility with naloxone. It elicits analgesia and possesses some sedative effect but has no amnestic properties. Its peak effect is observed 15-30 min after IV administration and 30-60 min after IM administration.

For procedural analgesia and sedation in children, morphine sulfate is given in a dosage of 0.08-0.1 mg/kg/dose IV, IM, or SC before the procedure and every 5-10 minutes as needed.

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