How is the risk of sepsis minimized in pediatric patients with sickle cell disease (SCD) and fever?

Updated: Sep 01, 2021
  • Author: Hina Z Ghory, MD; Chief Editor: Russell W Steele, MD  more...
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Patients with sickle cell disease (SCD) are considered functionally asplenic. Asplenic patients are at exceptional high risk of sepsis due to encapsulated organisms, such as Streptococcus pneumonia. Because of this, patients with SCD are often hospitalized for observation and empiric treatment. If these patients present with fever, they are considered at higher risk for occult bacteremia and treated accordingly. Blood cultures, CBCs, and differentials are assessed. Parenteral antibiotics against encapsulated organisms are given early.

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