Which medications in the drug class Anti-infective Agents are used in the treatment of Appendicitis?

Updated: Jul 23, 2018
  • Author: Sandy Craig, MD; Chief Editor: Barry E Brenner, MD, PhD, FACEP  more...
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Answer

Anti-infective Agents

Anti-infectives such as metronidazole and tigecycline are effective against many types of bacteria that have become resistant to other antibiotics.

Metronidazole (Flagyl)

Metronidazole has broad gram-negative and anaerobic coverage and is used in combination with aminoglycosides (eg, gentamicin). This agent appears to be absorbed into cells; intermediate metabolized compounds bind DNA and inhibit protein synthesis, causing cell death.

Tigecycline (Tygacil)

Tigecycline is a glycylcycline antibiotic that is structurally similar to tetracycline antibiotics. It inhibits bacterial protein translation by binding to the 30S ribosomal subunit, and it blocks entry of amino-acyl tRNA molecules into the ribosome A site.


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