Which medications in the drug class Aminoglycosides are used in the treatment of Appendicitis?

Updated: Jul 23, 2018
  • Author: Sandy Craig, MD; Chief Editor: Barry E Brenner, MD, PhD, FACEP  more...
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Aminoglycosides have concentration-dependent bactericidal activity. These agents work by binding to the 30S ribosome, inhibiting bacterial protein synthesis.

Gentamicin (Gentacidin, Garamycin)

Gentamicin is an aminoglycoside antibiotic used for gram-negative coverage, as well as in combination with an agent against gram-positive organisms and another one against anaerobes. Gentamicin is not the drug of choice, but consider using this drug if penicillins or other less toxic drugs are contraindicated, when it is clinically indicated, and in mixed infections caused by susceptible staphylococci and gram-negative organisms. This agent may be administered intravenously or intramuscularly and has numerous regimens; the dose must be adjusted for creatinine clearance and changes in volume of distribution.

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