Which medications in the drug class Cephalosporins are used in the treatment of Appendicitis?

Updated: Jul 23, 2018
  • Author: Sandy Craig, MD; Chief Editor: Barry E Brenner, MD, PhD, FACEP  more...
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Cephalosporins are structurally and pharmacologically related to penicillins. They inhibit bacterial cell wall synthesis, resulting in bactericidal activity.

Cefotetan (Cefotan)

Cefotetan is a second-generation cephalosporin that is used as single-drug therapy for broad gram-negative and anaerobic coverage. Administer cefotetan with cefoxitin to achieve the effectiveness of single dose. Its half-life is 3.5 hours.

Cefoxitin (Mefoxin)

This drug is also a second-generation cephalosporin that is indicated as single agent for the management of infections caused by susceptible gram-positive cocci and gram-negative rods. It has a half-life of 0.8 hours.


Cefepime is a fourth-generation cephalosporin. It has gram-negative coverage comparable to ceftazidime but has better gram-positive coverage. Cefepime is a zwitter ion that rapidly penetrates gram-negative cells.

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