Is a triple screen of WBC count, CRP level, and neutrophilia effective in diagnosing appendicitis?

Updated: Jul 23, 2018
  • Author: Sandy Craig, MD; Chief Editor: Barry E Brenner, MD, PhD, FACEP  more...
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Answer

Mohammed et al prospectively studied 216 children admitted for suspected appendicitis and found a triple screen sensitivity of 86% and a negative predictive value of 81. [34] However, Yang et al found that only 6 of 740 patients with appendicitis had a WBC count less than 10,500 cells/μ L AND neutrophilia that was less than 75%, AND a normal CRP level, yielding a sensitivity of 99.2% for the "triple screen." [35]


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