What is the role of 5-alpha-reductase inhibitors in the treatment of chronic bacterial prostatitis (CBP)?

Updated: May 25, 2021
  • Author: Samantha D Kraemer, MD; Chief Editor: Edward David Kim, MD, FACS  more...
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Treatment with 5-alpha-reductase inhibitors (eg, finasteride, dutasteride) has been shown to be effective in relieving symptoms of prostatitis. In the REDUCE study, which was originally designed to evaluate whether treatment with dutasteride decreased prostate cancer risk in men with an elevated PSA, long-term use of dutasteride significantly reduced prostatitis-like symptoms, compared with placebo. [59]

A randomized, placebo-controlled pilot study by Nickel et al suggested that some men with category IIIA CPPS experience symptomatic improvement with finasteride. However, these authors concluded that the results did not justify recommending finasteride as monotherapy, except for men who also have benign prostatic hyperplasia. [60]

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