What is the course of antibiotic therapy for chronic bacterial prostatitis (CBP)?

Updated: May 25, 2021
  • Author: Samantha D Kraemer, MD; Chief Editor: Edward David Kim, MD, FACS  more...
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Antibiotic therapy begins with initial 4- to 6-week course. A second course of 4-6 weeks can be offered if a bacterial cause is confirmed or the first course resulted in a partial symptomatic response.

If bacterial cultures remain positive, longer treatment is necessary. The best results have been observed with a 12-week course of therapy, although maintaining patient compliance may be difficult with longer durations of treatment.

A second cycle of antibiotics can be considered if initial treatment fails, because according to some authors up to 20% of patients in whom initial treatment failed may be rescued by using a second cycle. [1] If the patient obtains no obvious symptomatic benefit from infection control or cultures are negative, repeated use of antibiotics should be avoided. [27]

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