What are indications and contraindications of external beam radiotherapy (EBRT) in prostate cancer?

Updated: Aug 17, 2020
  • Author: Isamettin Andrew Aral, MD, MS; Chief Editor: Edward David Kim, MD, FACS  more...
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External beam radiation therapy (EBRT) is commonly used in the treatment of patients who have a greater likelihood of non–organ-confined disease. For patients who decide against surgical intervention, determining the presence of non–organ-confined disease is typically based on a review of tumor-related variables that have been shown to correlate with extraglandular disease extension (eg, high stage, high Gleason scores, and high prostate-specific antigen [PSA] levels). Certain patients may not be optimal candidates for EBRT, such as those with a history of bowel disorders (including ulcerative colitis and diverticular disease) and those with poorly controlled diabetes. [10] These patients are known to have preexisting conditions that may place them at risk for either more intense morbidity or more protracted morbidity.

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