What is the first-line pharmacologic therapy for urge incontinence in neurogenic bladder?

Updated: Dec 24, 2020
  • Author: Bradley C Gill, MD, MS; Chief Editor: Edward David Kim, MD, FACS  more...
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Anticholinergic drugs are the first-line pharmacologic therapy in urge incontinence. They are effective in treating urge incontinence because they inhibit involuntary bladder contractions. They are also useful in treating urinary incontinence associated with frequency, urgency, and nocturnal enuresis. All anticholinergic drugs have similar performance profiles and toxicity. Potential adverse effects of all anticholinergic agents include blurred vision, dry mouth, heart palpitations, drowsiness, and facial flushing. When anticholinergic drugs are used in excess, acute urinary retention may occur.

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