What is the role of combination therapy in the treatment of neurogenic bladder?

Updated: Dec 24, 2020
  • Author: Bradley C Gill, MD, MS; Chief Editor: Edward David Kim, MD, FACS  more...
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When a single drug treatment does not work, combination therapy may be used. Generally, agents with different mechanisms of action must be combined in order to improve urge incontinence; for instance, the combination of a beta-3 agonist with an anticholinerigic can be used to treat detrusor overactivity. Together, those drugs produce a synergistic effect that relaxes the unstable bladder to hold in urine and prevents urge incontinence. However, anticholinergic adverse effects may be additive because both drugs have similar adverse reactions.

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