What is the role of lab tests in the workup of precancerous lesions of the prostate?

Updated: Feb 26, 2020
  • Author: Stanley A Brosman, MD; Chief Editor: Edward David Kim, MD, FACS  more...
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Answer

No routine laboratory tests are used to evaluate for the presence of HGPIN or ASAP. Once these conditions are identified, however, phenotypic biomarkers can be obtained for experimental purposes. [28] Such studies show that HGPIN is more closely related to carcinoma than to benign epithelium. Cytoplasmic expression of p160-erb -b3 and p185-erb -b2 is greater in HGPIN and cancer than in normal or hyperplastic epithelium.

HGPIN and high-grade cancer are associated with the loss of secretory markers (eg, PSA cytoskeletal proteins, glycoproteins). These markers have no specific clinical value in predicting the progression of PIN to cancer but lend further evidence to the concept that HGPIN is a precursor to cancer.


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