Which mitotic figures are characteristic of precancerous lesions of the prostate?

Updated: Feb 26, 2020
  • Author: Stanley A Brosman, MD; Chief Editor: Edward David Kim, MD, FACS  more...
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Answer

Answer

Mitotic figures are rare in the epithelium of benign and neoplastic prostate cells, but mitosis progressively increases during the transition from benign to PIN to malignancy. Mitotic figures in BPH are found in the basal cell, with a mean value of 0.002%. In PIN, most of the mitotic figures are located in the basal cells, with a diminishing number of such figures found as the layers reach the luminal surface. In HGPIN, the mean value of mitotic figures is 0.19% in the basal layer, 0.08% in the intermediate layers, and 0.05% in the superficial layer.


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