How does age affect the risk for precancerous lesions of the prostate?

Updated: Feb 26, 2020
  • Author: Stanley A Brosman, MD; Chief Editor: Edward David Kim, MD, FACS  more...
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HGPIN appears to precede cancer by more than 10 years, with a parallel age-related increase in the frequency of HGPIN and cancer. HGPIN has been found in 9% of men in the second decade of life, 22% of men in the third decade, and 40% of men in the fourth decade. The prevalence of HGPIN in men aged 80 years is 70%.

In a study of 256 patients, Lee et al found that the mean age of patients with PIN was 65 years, and the mean age of patients with cancer was 70 years. In the investigation, patients underwent ultrasonography-guided prostate biopsies. Cancer was found in 103 patients, and a combination of PIN and cancer was found in an additional 27 patients.

In a study of 195 radical prostatectomy specimens, Qian et al observed that the volume of HGPIN increased with age. [12]

However, although most studies indicate that the risk and extent of HGPIN and ASAP increase with patient age, McNeal and Bostwick reported that this correlation was not evident in patients with prostate cancer who were older than age 50 years. [11]

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