What is high-grade prostatic intraepithelial neoplasia (HGPIN)?

Updated: Feb 26, 2020
  • Author: Stanley A Brosman, MD; Chief Editor: Edward David Kim, MD, FACS  more...
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HGPIN is characterized by architecturally benign prostatic acini and ducts lined with atypical cells whose morphologic, histochemical, immunohistochemical, and genetic changes are similar to those of prostate cancer. [2] However, HGPIN does not invade the basement membrane of the prostatic glands.

Bostwick et al have described four architectural patterns of HGPIN: tufting, micropapillary, cribriform, and flat. [3] Tufting is the most common and is present in 97% of all HGPINs. Most histologic samples contain multiple patterns, and the various HGPIN patterns carry equivalent prognoses.

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