Which medications in the drug class Analgesics, Narcotic are used in the treatment of Nephrolithiasis?

Updated: Jan 13, 2020
  • Author: Chirag N Dave, MD; Chief Editor: Bradley Fields Schwartz, DO, FACS  more...
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Analgesics, Narcotic

Narcotic analgesics act at the central nervous system (CNS) mu receptors and are commonly used in the treatment of renal colic. They are inexpensive and proven effective. Disadvantages include sedation, respiratory depression, smooth muscle spasm, and potential for abuse and addiction.


Butorphanol is a mixed agonist-antagonist narcotic with central analgesic effects for moderately severe to severe pain. It causes less smooth muscle spasm and respiratory depression than morphine or meperidine. Weigh these advantages against the increased cost of butorphanol.

Morphine sulfate (Kadian, MS Contin, Infumorph 200, Infumorph 500)

Morphine is the principal opium alkaloid product. It is the drug of choice for parenteral use in the immediate management of pain due to renal (ureteral) colic.

Oxycodone and acetaminophen (Percocet, Endocet, Roxicet, Xartemis XR, Primlev)

Oxycodone-acetaminophen is a drug combination indicated for oral relief of moderate to severe pain. It is employed in medical expulsive therapy (MET).

Hydrocodone and acetaminophen (Vicodin, Vicodin ES, Lortab, Norco, Zamicet)

Hydrocodone is also combined with acetaminophen. This drug combination is indicated for oral relief of moderate to severe pain.

Meperidine (Demerol)

Meperidine is a narcotic analgesic with multiple actions similar to those of morphine. It may produce less constipation, smooth muscle spasm, and depression of cough reflex than similar analgesic doses of morphine.


Nalbuphine is a synthetic opioid agonist-antagonist potent analgesic. It stimulates kappa opioid receptor in the CNS, which causes inhibition of ascending pain pathways. It is indicated for the relief of moderate to severe pain.

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