What is synovial sarcoma?

Updated: Mar 02, 2019
  • Author: Michael J Duh, MD; Chief Editor: Felix S Chew, MD, MBA, MEd  more...
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Synovial sarcoma constitutes 8-10% of all sarcomas and usually involves the extremities (as demonstrated in the images below), especially the lower extremities around the knees. Synovial sarcoma is frequently misdiagnosed as a benign condition because of its often small size, slow growth, and well-defined appearance. This malignancy is driven by a translocation between SS18 and SSX 1, 2, or 4 (hybrid transcription factor SS18:SSX). Approximately 1,000 cases a year are diagnosed n the United States, most commonly between 15 and 30 years of age. [1, 2, 3, 4, 5]

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