Which radiographic findings are characteristic of recurrent thoracic non-Hodgkin lymphoma (NHL)?

Updated: Mar 05, 2019
  • Author: Ali Nawaz Khan, MBBS, FRCS, FRCP, FRCR; Chief Editor: Eugene C Lin, MD  more...
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Recurrent disease after treatment tends to occur at the initial site of presentation. On plain radiographs and CT scans, recurrent disease appears as nodular opacities or attenuations, as ill-defined parahilar opacities or attenuations, or as large, masslike lesions in the lung. Paracardiac or diaphragmatic lymphadenopathy is a relatively common feature of recurrent disease; this is particularly the case in HD, because these lymph nodes are not included in the mantle radiation treatment field.

Recurrence in previously irradiated intrathoracic lymph nodes, although uncommon, may occur, particularly in patients with initially large mediastinal masses. In most patients with recurrent NHL, relapse ensues within 2 years of completion of treatment. Plain radiographs and/or CT scans show an increase in the size of one or more masses.

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