Which types of non-Hodgkin lymphomas (NHL) have a predilection for the mediastinum?

Updated: Mar 05, 2019
  • Author: Ali Nawaz Khan, MBBS, FRCS, FRCP, FRCR; Chief Editor: Eugene C Lin, MD  more...
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Most histologic types of lymphoma can involve the mediastinum. However, some lymphomas have a predilection for the mediastinum; these include the following:

  • Nodular sclerosis HD - Classically seen in young women

  • Lymphoblastic lymphoma - Occurs in children and can grow rapidly

  • Diffuse large-cell type of lymphoma - Can occur at any age

While it is true that large-cell NHL favors the anterior mediastinum, follicular low- or intermediate-grade NHL, as well as high-grade NHL, can involve nodes anywhere in the chest and axillae.

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