Is anakinra (Kineret) safe for pregnant women with rheumatoid arthritis (RA)?

Updated: May 11, 2018
  • Author: Katherine K Temprano, MD; Chief Editor: Christine Isaacs, MD  more...
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Anakinra (Kineret), an interleukin 1 receptor antagonist, is used to treat severe RA. Anakinra is a pregnancy category B medication. No adverse effects have been reported in rats and rabbits receiving up to 100 times the recommended human dose. No data are available to indicate whether anakinra is excreted in human milk. 

Very little information is available on its effects in pregnancy.  Less than 20 cases have been reported in the literature. The largest series evaluated 9 births to women with cryopyrin-associated periodic syndromes and anakinra exposure. There was a single fetus of a twin pregnancy that died in the setting of renal agenesis with an NLRP3 mutation. No other birth defects or premature delivery were noted. [50]

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