What are the guidelines on the use of leflunomide (LEF) by pregnant women with rheumatoid arthritis (RA)?

Updated: May 11, 2018
  • Author: Katherine K Temprano, MD; Chief Editor: Christine Isaacs, MD  more...
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Both the EULAR and BSR-BHPR guidelines recommend avoiding leflunomide in pregnancy and completing a cholestyramine washout procedure prior to conception. [18, 19]  BSR-BHPR guidelines further recommend that if accidental conception occurs during leflunomide therapy, the drug should be stopped immediately and cholestyramine washout given until plasma levels are undetectable. [19]

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