What is included in the methotrexate regimen to induce remission in localized or milder granulomatosis with polyangiitis (GPA)?

Updated: Aug 31, 2021
  • Author: Christopher L Tracy, MD; Chief Editor: Herbert S Diamond, MD  more...
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20-25 mg weekly, oral or subcutaneous

Must have normal renal function (ie, Cr < 1.5mg/dL)

Given with folic acid 1mg/day to lessen some adverse effects

Required laboratory monitoring - CBC, Cr, LFTs

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