What is included in the cyclophosphamide regimen to induce remission in severe or generalized granulomatosis with polyangiitis (GPA)?

Updated: Aug 31, 2021
  • Author: Christopher L Tracy, MD; Chief Editor: Herbert S Diamond, MD  more...
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Oral dosing - 2 mg/kg/day (max 200 mg/day); adjust dose as needed for elderly age or renal insufficiency; also adjust dose as needed to keep white blood cells (WBCs) >3.5 and/or absolute neutrophil count (ANC) >1Njiroveci pneumonia prophylaxis recommended

Required labor atory monitoring - CBC, creatinine (Cr), liver function tests (LFTs), urinalysis (UA), +/- urine cytology

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