What is the prevalence of cardiac involvement in granulomatosis with polyangiitis (GPA)?

Updated: Aug 31, 2021
  • Author: Christopher L Tracy, MD; Chief Editor: Herbert S Diamond, MD  more...
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Cardiac involvement most often consists of pericarditis or coronary vasculitis, but myocarditis, endocarditis, conduction system granulomata, and valvular involvement may also occur. [51] Necrotizing vasculitis of the coronary vessels can result in myocardial infarction or sudden death.

Estimates of the frequency of cardiac involvement vary widely, with a North American study reporting a rate of 33.3% and no association with a higher rate of relapse or premature death, [52] while a European study reported cardiac involvement in 46% of GPA patients assessed with electrocardiography and echocardiography, along with increased all-cause and cardiovascular mortality. [53]

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