Which routine lab test results suggest granulomatosis with polyangiitis (GPA)?

Updated: Aug 31, 2021
  • Author: Christopher L Tracy, MD; Chief Editor: Herbert S Diamond, MD  more...
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Answer

Routine laboratory tests are nonspecific in GPA. Results may include the following:

  • Abnormal kidney function tests and urinalysis in patients with renal involvement

  • Rheumatoid factor is positive in a low titer in two thirds of patients

  • CBC: Mild normochromic normocytic anemia is present in 50% of patients; leukocytosis is common, with a neutrophil predominance

  • Elevated inflammatory markers (ESR, CRP)


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