What are the pulmonary signs and symptoms of granulomatosis with polyangiitis (GPA)?

Updated: Aug 31, 2021
  • Author: Christopher L Tracy, MD; Chief Editor: Herbert S Diamond, MD  more...
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Pulmonary involvement in GPA can be asymptomatic, insidious in onset, or severe and fulminant. Pulmonary disease may cause any of the following:

  • Pulmonary infiltrates (71%)

  • Cough (34%)

  • Hemoptysis (18%)

  • Chest discomfort (8%) [2]

  • Dyspnea (7%) [2]

  • Diffuse alveolar hemorrhage due to alveolar capillaritis (5%-45%) [3]

  • Atelectasis, with dullness on percussion, decreased breath sounds, and crackles on auscultation

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