What are the hallmark features of granulomatosis with polyangiitis (GPA)?

Updated: Aug 31, 2021
  • Author: Christopher L Tracy, MD; Chief Editor: Herbert S Diamond, MD  more...
  • Print
Answer

Granulomatosis with polyangiitis (GPA), formerly known as Wegener granulomatosis, is a rare multisystem autoimmune disease of unknown etiology. Its hallmark features include necrotizing granulomatous inflammation and pauci-immune vasculitis in small- and medium-sized blood vessels. See the image below.

Necrotic, purpuric, and blistering plaque on the w Necrotic, purpuric, and blistering plaque on the wrist in a patient with granulomatosis with polyangiitis.

See Vasculitis: Case Presentations, a Critical Images slideshow, for more information on clinical, histologic, and radiographic imaging findings in various forms of vasculitis.


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!