Which medications are used in the treatment of Sjögren syndrome?

Updated: Mar 05, 2021
  • Author: Sriya K Ranatunga, MD, MPH; Chief Editor: Herbert S Diamond, MD  more...
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Most patients with Sjögren syndrome can be cared for adequately with topical therapy and with avoidance of medications that exacerbate their symptoms. Pilocarpine or cevimeline can be used in cases of xerostomia for which systemic therapy is needed or local therapy is not successful.

Rituximab has shown promise in the treatment of patients with severe extraglandular manifestations of Sjögren syndrome, such as vasculitis, cryoglobulinemia, and peripheral neuropathy. [85, 86] Although some data support its efficacy for glandular involvement, it is not currently used for treatment of sicca symptoms alone.

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