What are possible adverse effects of rituximab in the treatment of Sjögren syndrome?

Updated: Mar 05, 2021
  • Author: Sriya K Ranatunga, MD, MPH; Chief Editor: Herbert S Diamond, MD  more...
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Patients and health care providers should be aware that, although uncommon, significant harms may be associated with the use of rituximab and should exercise caution and observe for the following when using rituximab in patients with Sjögren syndrome:

  • Infusion reactions
  • Tumor lysis syndrome in patients with non-Hodgkin lymphoma
  • Progressive multifocal leukoencephalopathy
  • Hepatitis B reactivation with possible fulminant hepatitis
  • Severe mucocutaneous reactions
  • Infections
  • Bowel obstruction and perforation
  • Cardiac arrhythmias and angina
  • Cytopenias
  • Serious bacterial, viral, or fungal infections

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