How frequently is rheumatoid factor present in Sjögren syndrome?

Updated: Mar 05, 2021
  • Author: Sriya K Ranatunga, MD, MPH; Chief Editor: Herbert S Diamond, MD  more...
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RF is present in 52% of patients with primary Sjögren syndrome and in 98% of patients with the secondary disease, occurring even when rheumatoid arthritis is not present. Consider a diagnosis of  rheumatoid arthritis if the patient has symmetrical polyarticular synovitis.

The presence of RF has been independently associated with elevated risk for lymphoma in patients with primary Sjögren syndrome. [68] However, loss of a previously positive RF finding can be observed in some patients with Sjögren syndrome who develop lymphoma.

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