Which lab test results suggest Sjögren syndrome?

Updated: Mar 05, 2021
  • Author: Sriya K Ranatunga, MD, MPH; Chief Editor: Herbert S Diamond, MD  more...
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Laboratory test results may indicate the following:

  • Elevated erythrocyte sedimentation rate (ESR)

  • Anemia

  • Leukopenia

  • Eosinophilia

  • Hypergammaglobulinemia

  • Presence of antinuclear antibodies (ANAs), especially anti-Ro and anti-La

  • Presence of rheumatoid factor (RF)

  • Presence of anti–alpha-fodrin antibody (reliable diagnostic marker of juvenile Sjögren syndrome)

  • Creatinine clearance may be diminished in up to 50% of patients

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