What conditions should be included in the differential diagnoses of Sjögren syndrome in patients with parotid enlargement?

Updated: Mar 05, 2021
  • Author: Sriya K Ranatunga, MD, MPH; Chief Editor: Herbert S Diamond, MD  more...
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Differential diagnoses to consider in patients with parotid enlargement include the following:

  • Viral infection (eg, mumps, Epstein-Barr virus, cytomegalovirus, coxsackievirus A, influenza)

  • DILS associated with HIV disease

  • Granulomatous diseases (sarcoidosis, tuberculosis, leprosy)

  • Hyperlipoproteinemia

  • Hepatic cirrhosis

  • Hepatitis C

  • Bulimia

  • Recurrent parotiditis of childhood

  • Chronic pancreatitis

  • Acromegaly

  • Amyloidosis

  • Gonadal hypofunction

  • Diabetes mellitus

  • Salivary gland tumor (primarily unilateral)

  • Bacterial infection (primarily unilateral)

  • Chronic sialadenitis (primarily unilateral)

  • Lymphoma

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