What conditions should be included in the differential diagnoses of Sjögren syndrome in patients with sicca symptoms?

Updated: Mar 05, 2021
  • Author: Sriya K Ranatunga, MD, MPH; Chief Editor: Herbert S Diamond, MD  more...
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Differential diagnoses to consider in patients with sicca include the following:

  • Medications (eg, antidepressants, anticholinergics, beta-blockers, diuretics, antihistamines, some antiarrhythmic and antiepileptic drugs)

  • Anxiety and depression

  • Viral infections (eg, mumps)

  • Complications from contact lenses

  • Dehydration

  • Hypervitaminosis A

  • Neurotropic keratitis

  • Mucous membrane pemphigoid

  • Environmental irritants

  • Mouth breathing

  • Chronic blepharitis

  • Chronic conjunctivitis

  • Rosacea

  • Therapeutic radiation or surgery to the head and neck

  • Age

  • Alzheimer disease

  • Parkinson disease

  • Bell palsy

  • Amyloidosis

  • Sarcoidosis

  • Lymphoma

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