Which urinary conditions are associated with Sjögren syndrome?

Updated: Mar 05, 2021
  • Author: Sriya K Ranatunga, MD, MPH; Chief Editor: Herbert S Diamond, MD  more...
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Patients with Sjögren syndrome have significantly more urinary problems than do those without Sjögren syndrome. Patients may have the following:

  • Irritated bladder

  • Suprapubic pain

  • Renal tubular dysfunction - Patients with primary Sjögren syndrome commonly are first seen because of renal impairment, usually from renal tubular dysfunction [58]

  • Renal tubular acidosis - This affects one third of patients with Sjögren syndrome; a correlation apparently exists between hypergammaglobulinemia and distal renal tubular acidosis [58]

  • Interstitial nephritis - This is rare, occurring in 4% of cases; it is often accompanied by cryoglobulinemia, a decreased level of complement, and the presence of circulating immune complexes

  • Impaired renal concentrating ability, generalized aminoaciduria

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