What are the risk factors for lymphoma in Sjögren syndrome?

Updated: Mar 05, 2021
  • Author: Sriya K Ranatunga, MD, MPH; Chief Editor: Herbert S Diamond, MD  more...
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Risk factors for lymphoma include the following;

  • Salivary gland enlargement
  • Regional or generalized lymphadenopathy
  • Hepatosplenomegaly
  • Palpable purpura
  • Leukopenia
  • Renal insufficiency
  • Loss of a previously positive polyclonal gammopathy
  • Development of a monoclonal gammopathy or a monoclonal cryoglobulinemia
  • RF positivity
  • Anti-SSA/SSB positivity
  • Hypocomplementemia

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