What are the possible complications of Sjögren syndrome?

Updated: Mar 05, 2021
  • Author: Sriya K Ranatunga, MD, MPH; Chief Editor: Herbert S Diamond, MD  more...
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Answer

Complications related to Sjögren syndrome include the following (see Prognosis, Treatment, and Medication):

  • Emergence of disorders associated with Sjögren syndrome, such as SLE and RA

  • Infection of the parotid gland, typically staphylococcal, streptococcal, or pneumococcal - clues include unilateral worsening of symptoms, along with tenderness, warmth, and erythema

  • Emergence of parotid tumors - watch for unusually hard or unilateral parotid enlargement

  • Pregnant patients with antiRo/SS-A antidodies are at risk for fetal loss, complete heart block in the fetus ,and neonatal lupus syndrome in the newborn

  • Emergence of pseudolymphomas (pleomorphic cells that do not meet the criteria for malignancy) and non-Hodgkin B-cell lymphomas (see the image below) [5]

Clinical photograph and photomicrograph of a 48-ye Clinical photograph and photomicrograph of a 48-year-old man with Sjögren syndrome with a large left parotid mass. On biopsy, B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type was identified. Microscopic section of parotid biopsy, stained with immunoperoxidase for kappa light chains (brown-stained cells), showed monoclonal population of B cells, confirming the diagnosis.

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