What are the EULAR treatment guidelines for dry eyes in Sjögren syndrome?

Updated: Mar 05, 2021
  • Author: Sriya K Ranatunga, MD, MPH; Chief Editor: Herbert S Diamond, MD  more...
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The first-line therapeutic approach to ocular dryness includes the use of artificial tears and ocular gels/ointments. Refractory/severe ocular dryness may be managed in stepwise fashion, as follows:

  1. Topical ocular non-steroidal anti-inflammatory drugs (NSAIDs) or corticosteroids may be prescribed by ophthalmologists as a short-term therapeutic approach (maximum 2–4 weeks); if no response or intolerance, then
  2. Topical cyclosporine; if no response or intolerance, then
  3. Serum eye drops; if no response or intolerance, then 
  4. Rescue therapies - Oral muscarinic agonists or plug insertion

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