How is eosinophilic fasciitis (EF) differentiated from other cutaneous disorders?

Updated: Dec 24, 2020
  • Author: Peter M Henning, DO; Chief Editor: Herbert S Diamond, MD  more...
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Differential considerations include the following:

  • The localized forms of scleroderma, morphea, and linear forms of scleroderma

  • Limited and diffuse cutaneous systemic sclerosis

  • Other localized cutaneous fibrosing disorders, eg, nephrogenic systemic fibrosis, scleromyxedema, and scleredema

In general, these alternative etiologies can be excluded by the absence of peripheral eosinophilia. However, cases of diffuse morphea with features that overlap with eosinophilic fasciitis have been reported. [38, 39] The absences of Raynaud phenomenon, abnormal capillaroscopy findings, and visceral involvement are key findings that differentiate eosinophilic fasciitis (EF) from systemic sclerosis

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