How is heterotopic ossification prevented in traumatic brain injury (TBI)?

Updated: Mar 02, 2020
  • Author: Percival H Pangilinan, Jr, MD; Chief Editor: Stephen Kishner, MD, MHA  more...
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The mainstay of preventing heterotopic ossification in patients with TBI is ROM exercise. The use of forceful ROM is somewhat controversial because it is thought to be a cause of heterotopic ossification, but data from human studies have not demonstrated this mechanism.

The prophylactic role of nonsteroidal anti-inflammatory drugs (NSAIDs), low-dose radiation, or bisphosphonates remains unclear. NSAIDs and etidronate can help with pain management. The risks and benefits of these drugs in managing established heterotopic ossification should be assessed.

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