Which medications in the drug class Nonsteroidal anti-inflammatory drugs (NSAIDs) are used in the treatment of Sarcoidosis?

Updated: Sep 15, 2020
  • Author: Nader Kamangar, MD, FACP, FCCP, FCCM; Chief Editor: Zab Mosenifar, MD, FACP, FCCP  more...
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Answer

Nonsteroidal anti-inflammatory drugs (NSAIDs)

NSAIDs are indicated for arthralgias and other rheumatic complaints and not for significant pulmonary disease. Patients with stage I sarcoidosis require only occasional treatment with NSAIDs.

Naproxen (Aleve, Anaprox, Naprelan, Naprosyn)

Naproxen is used for relief of mild to moderate pain; it inhibits inflammatory reactions and pain by decreasing the activity of cyclooxygenase, which results in a decrease of prostaglandin synthesis.

Flurbiprofen

Flurbiprofen may inhibit cyclo-oxygenase, which, in turn, inhibits prostaglandin biosynthesis. These effects may result in analgesic, antipyretic, and anti-inflammatory activities.

Ibuprofen (Motrin, Ibuprin, Advil, Addaprin, Neoprofen)

Ibuprofen and other NSAIDs are useful in the management of joint complaints. It inhibits inflammatory reactions and pain by decreasing the activity of cyclooxygenase, which results in a decrease of prostaglandin synthesis.

Ketoprofen

Ketoprofen is indicated for relief of mild to moderate pain and inflammation. Small initial dosages are indicated in small and elderly patients and in those with renal or liver disease. It inhibits inflammatory reactions and pain by decreasing the activity of cyclooxygenase, which results in a decrease of prostaglandin synthesis.

Indomethacin (Indocin)

Indomethacin inhibits inflammatory reactions and pain by decreasing the activity of cyclooxygenase, which results in a decrease of prostaglandin synthesis. It is rapidly absorbed and metabolism occurs in the liver by demethylation, deacetylation, and glucuronide conjugation.


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