Which medications in the drug class Antimetabolites are used in the treatment of Sarcoidosis?

Updated: Sep 15, 2020
  • Author: Nader Kamangar, MD, FACP, FCCP, FCCM; Chief Editor: Zab Mosenifar, MD, FACP, FCCP  more...
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Answer

Antimetabolites

Given the adverse effect profile of corticosteroids, methotrexate has recently received significant attention as either a corticosteroid alternative or a corticosteroid-sparing agent.

Methotrexate (Folex PFS, Rheumatrex, Otrexup)

Methotrexate is an antimetabolite that interferes with folate metabolism. It is cell cycle specific. Actively proliferating cells are more susceptible to its effects.


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