What is the role of angiotensin-converting enzyme (ACE) measurement in the workup of sarcoidosis?

Updated: Sep 15, 2020
  • Author: Nader Kamangar, MD, FACP, FCCP, FCCM; Chief Editor: Zab Mosenifar, MD, FACP, FCCP  more...
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Answer

ACE levels may be elevated. NCGs secrete ACE, which may function as a cytokine. Serum ACE levels are elevated in 60% of patients at the time of diagnosis. Serum ACE levels may correlate with total body granuloma load. Levels may be increased in fluid from bronchoalveolar lavage or in cerebrospinal fluid. Sensitivity and specificity as a diagnostic test is limited (60% and 70%, respectively). There is no clear prognostic value. Serum ACE levels may decline in response to therapy. Decisions on treatment should not be based on the ACE level alone.


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