What are the possible psychiatric comorbidities of sarcoidosis?

Updated: Sep 15, 2020
  • Author: Nader Kamangar, MD, FACP, FCCP, FCCM; Chief Editor: Zab Mosenifar, MD, FACP, FCCP  more...
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Sarcoidosis is associated with fatigue and a high rate of psychiatric comorbidity. In one study, 44% of the subjects met the diagnostic criteria for at least one Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) axis I disorder. Specifically, 25% of subjects met the criteria for major depressive disorder, 6.3% for panic disorder, 6.3% for bipolar disorder, 5% for generalized anxiety disorder, and 1.3% for obsessive-compulsive disorder. [40]

One double-blind, randomized trial found that the treatment with dexmethylphenidate hydrochloride was associated with a significant improvement in sarcoidosis-associated fatigue. [41]

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